Citation: LIN Sicong, WANG Jin, LIU Xiaoning, TU Xiangton, Charles L. Liotta. SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALSⅡ. SYNTHESIS OF POLY(ETHYLENEGLYCOL MONOMETHYLLTHER ) METHACRYLATE AND ANTITHROMBOGENICITY OF ITS COPOLYMERS[J]. Chinese Journal of Polymer Science, ;1992, 10(2): 119-126. shu

SYNTHETIC STUDIES ON BLOOD COMPATIBLE BIOMATERIALSⅡ. SYNTHESIS OF POLY(ETHYLENEGLYCOL MONOMETHYLLTHER ) METHACRYLATE AND ANTITHROMBOGENICITY OF ITS COPOLYMERS

Received Date: 12 March 1991

Poly (ethyleneglycol monomethylether) methacrylate (PEGMM)was synthesized by means of the reaction of methacrylyl chloride with sodium monomethylpolyethyleneglycoxide and was characterized by FTIR, 1H-NMR,and ultraviolet spectrometries. A series of poly (vinyl alcohol)-graft-PEGMM (PVA-g-PEGMM )and methyl methacrylate-PEGMM copolymer (PMMA-PEGMM) were prepared and tested for antithrombogenicity in vitro. The results indicate that the antithrombogenicity of the copolymers basically increases with the increasing of the DP of polyoxyethylene (POE) chain and tends to a plateau after the DP around 114,i.e.the long chain structure of POE is favourable to the antithrombogenicity of its copolymers;moreover,the extent of the improbement of antithrombogenicity also relates to the PEGMM content of the copolymers and the kind of the matrix that the POE chains are located on.These results are consistent with the anticipation of the hypothesis of maintaining proteins'normal conformations for blood compatible biomaterials.
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