Citation: Yan Guang WANG, Jian Lin PAN, Yao Zu CHEN. Synthesis and Antitumor Activity of New Derivatives of Podophyllotoxin[J]. Chinese Chemical Letters, ;1996, 7(11): 987-988. shu

Synthesis and Antitumor Activity of New Derivatives of Podophyllotoxin

Department of Chemistry Zhejiang Uaiversity,Hangzhou 310027

Received Date: 22 April 1996

Fund Project: The authors are grateful for financial support for this work from National Natural Science Foundation of China.

A series of analogues of etoposide(VP-16),the C-4 alkylamino-substituted 4'-demethyl-epipodophyllotoxins,have been synthesized and studied for their activity to inhibit L1210 and KB cells in vitro.Most new compounds are as active or more active than VP-16 in their inhibition of both L1210 and KB cells.
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