Citation: Ji Fang WENG, Xing Tao SONG, Liang LI, Hui Feng QIAN, Ke Ying CHEN, Xue Ming XU, Cheng Xi CAO, Ji Cun REN. Exploring Feasibility for Application of Luminescent CdTe Quantum Dots Prepared in Aqueous Phase to Live Cell Imaging[J]. Chinese Chemical Letters, ;2006, 17(5): 675-678. shu

Exploring Feasibility for Application of Luminescent CdTe Quantum Dots Prepared in Aqueous Phase to Live Cell Imaging

1.
College of Chemistry & Chemical Engineering,;
2.
College of Life Science & Biotechnology, Shanghai Jiaotong University, Shanghai 200240

Received Date: 23 November 2005

Fund Project: This work was financially supported by the National Natural Science Foundation of China (No. 20335020, 90408014), and the Nano-Science Foundation of Shanghai (0452NM052, 05NM0500-2).

This paper explored the feasibility for the application of luminescent CdTe quantum dots prepared in aqueous phase to live cell imaging. The highly luminescent CdTe quantum dots (QDs)were first prepared in aqueous phase, and then were covalently coupled to a plant lectin (UEA-1), as a fluorescent probe. After incubating with of human umbilical vein endothelial cells (HUVECs), the QD probe with UEA-1 was able to specifically bind the corresponding cell receptor. The good cell images were obtained in live cells using laser confocal scanning microscopy. We predict that QDs prepared in water phase will probably become an attractive alternative probe in cellular imaging and bio-labeling.
- CdTe quantum dots,
- aqueous synthesis,
- HUVEC,
- UEA-1
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