Citation: DING Qiong, ZHANG Lina, ZENG Fanbo. INFLUENCE OF MOLECULAR WEIGHT AND PERIODATE-MODIFICATION OF β-D-GLUCANS FROM PORIA COCOS SCLEROTIUM ON ANTITUMOR ACTIVITIES*[J]. Chinese Journal of Polymer Science, ;1998, 16(1): 62-66. shu

INFLUENCE OF MOLECULAR WEIGHT AND PERIODATE-MODIFICATION OF β-D-GLUCANS FROM PORIA COCOS SCLEROTIUM ON ANTITUMOR ACTIVITIES*

Received Date: 12 May 1997

In this work, influence of molecular weight and periodate modification ofβ-D-glucans isolated from Poria cocos sclerotium on the antitumor activities against Sar-coma 180 and Ehrlich ascites carcinoma (EAC) tumor was studied. The results show thattwo glucans PC3 (linear β-(1→3)-D-glucan) and PC4 [β-(1→3)-D-glucan with a fewof branches and glucuronic acid] are devoid of antitumor activity. However, when theglucans were modified by periodate oxidation, borohydride reduction and mild hydrolysis or partially hydrolysis,the derivatives have obvious antitumor activities.The decrease in molecular weight of glucans after periodate modification hardly affects their antitumor actions,but on the other hand,the decrease of molecular weight without periodate modification could lead to an enhancement of the antitumor activities.Moreover,the glucans and these derivatives have much higher enhancement ratios of body weight of mice than that of --Fluorouracil (5-Fu),suggesting that they are less toxic than 5-Fu.
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