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Citation: Tian Zhenfen, Lv Wenhua, Gong Yabin, Zhang Zhaoyue, Chen Yunqi, Zou Aihua. Preparation and Characterization of Bufalin Nanostructure Lipid Carrier[J]. Chemistry, ;2017, 80(7): 679-683. shu

Preparation and Characterization of Bufalin Nanostructure Lipid Carrier

1.
School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237
2.
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, 200437
3.
International College of Engineering, East China University of Science and Technology, Shanghai 200237

Corresponding author: Zou Aihua, aihuazou@ecust.edu.cn
Received Date: 10 January 2017
Accepted Date: 3 March 2017

Figures(3)

In this paper, Bufalin loaded nanostructure lipid carrier (BUF-NLC) was successfully prepared by high pressure homogenization. The physicochemical properties, in vitro release and cytotoxicity (MTT) were characterized. The results indicated that BUF-NLC has small particle size, good dispersibility and stability. The MTT test suggested that the cytotoxicity of BUF-NLC on tumor cells was lower than free BUF in the initial stage, but after prolonged the action time, the cytotoxicity of BUF-NLC was consistent with that of BUF, indicating that NLC package does not reduce the cytotoxicity of BUF, but gradually release it, which was very important to overcome the side-effects caused by the high toxicity of BUF.
- Bufalin (BUF),
- Nanostructure lipid carrier (NLC),
- Sustained release,
- Toxicity
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