Citation: . GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*[J]. Chinese Journal of Polymer Science, ;2003, 21(4): 419-425. shu

GRAFTING OF SULFOBETAINE ONTO A POLYURETHANE SURFACE TO IMPROVE BLOOD COMPATIBILITY*

Received Date: 11 July 2002
Revised Date: 7 November 2002

On the molecular level, it is believed that polymers containing zwitterionic structures should be compatible withblood. In this work polyurethane films were grafted with sulfobetaine by a three-step procedure. In the first step, the films'surfaces were treated with hexamethylene diisocyanate (HDI) in toluene at 50℃ in the presence of di-n-butyl tin dilaurate(DBTDL) as a catalyst. The extent of the reaction was monitored by ATR-IR spectra; a maximum number of free NCO groups was obtained after a reaction time of 90 min.In the second step,the hydroxyl groups of N,N-dimethylethanolamine(DMEA) were allowed to react in toluene with NCO groups bound on the surface.In the third step,sulfobetaines were formed on the surface through the ring-opening reaction between tertiary amine of DMEA and 1,3-propanesultone(PS).The surfaces of the films were characterized by ATR-IR and XPS showing that the grafted surfaces were composed of sulfobetaine.The results of the contact angle measurement show that the surface was strongly hydrophilic.The platelet adhesion test demonstrated that the films grafted with sulfobetaine have excellent blood compatibility.
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