Citation: Zi Li XIAO, Ren WEN, An Gou MO, Xi Peng JING, Feng Yan SUN. 1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR[J]. Chinese Chemical Letters, ;1991, 3(9): 677-680. shu

1-SUBSTITUTED PHENYL-β-CARBOLINES:SYNTHESIS AND SPECIFIC BINDING WITH BENZODIAZEPINE RECEPTOR

a Dept of Medicinal Chemistry Shanghai Medical University(SMU);
b Lab of Isotope SMU;
c Dept of Neurobiology SMU Shanghai 200032

Received Date: 16 June 1991

By the condensation of tryptamine with appropriate substituted benzaldehyde followed by Pictet-Spengler reaction, a series of 1-aryl-tetrahydro-β-carbo-lines(THβCs)were obtained.After dehydrogenation using sulfur, Pd-C or lead tetraacetate(LTA), these THβCs can give the corresponding β-carbolines(βCs)which exhibit specific binding with rat brain benzodiazepine receptor in vitro.
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