Citation: Rahul R. NAGAWADE, Devanand B. SHINDE. BF₃·OEt₂ Promoted Solvent-free Synthesis of Benzimidazole Derivatives[J]. Chinese Chemical Letters, ;2006, 17(4): 453-456. shu

BF₃·OEt₂ Promoted Solvent-free Synthesis of Benzimidazole Derivatives

Rahul R. NAGAWADE ^1,2, ,
Devanand B. SHINDE ²

1.
Division of Medicinal Chemistry-New Drug Discovery, Wockhardt Research Centre, Aurangabad-431210(M. S.), India;
2.
Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad-431004(M. S.), India

Received Date: 15 September 2005

Fund Project: The authors are thankful to the Head, Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004 -(M.S.), India for providing laboratory facility.

Differently substituted benzimidazoles have been synthesized in very good yields in solvent-free clnditions from o-phenlenediame and aldehydes im the pressemce of BF₃·OEt₂ as acatalyst. The method is applicable to aromatic, unsaturated and aliphatic aldehydes and to substituted o-phenylenediamines without significant differences.
- BF₃·OEt₂,
- aldehydes,
- benzimidazoles,
- solvent-free reactions,
- drugs
1. [1]
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18. [18]
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