Citation: Xin Rong QIN, Yu Li XIE, Qiao Ling ZHANG, Hui Bing LUO, Yu Yuan XIE. Synthesis of (2R, 4R)-2-N-tert-Butyloxycarbonyl Amino-4, 5-epoxido-valeric Acid Methyl Ester[J]. Chinese Chemical Letters, ;2002, 13(2): 111-112. shu

Synthesis of (2R, 4R)-2-N-tert-Butyloxycarbonyl Amino-4, 5-epoxido-valeric Acid Methyl Ester

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031

Received Date: 28 May 2001

The stereoselective synthesis of (2R, 4R)-2-N-tert-butyloxycarbonyl amino-4, 5-epoxido-valeric acid methyl ester 8, which is the key intermediate for the synthesis of (2'S, 2R)-3-trans-nitrocyclopropyl-alanine, was first accomplished.
- Amino acid,
- epoxide,
- chiral
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