Citation: Xiao Tao LI, Guang Guang JIANG, Yue Hua SHI, Zhu De XU. Enantiomeric Resolution on L-Carnitine Selective Polymers Prepared by Molecular Imprinting[J]. Chinese Chemical Letters, ;2002, 13(2): 157-158. shu

Enantiomeric Resolution on L-Carnitine Selective Polymers Prepared by Molecular Imprinting

1.
Department of Chemistry, Yuquan Campus of Zhejiang University, Hangzhou 310027;
2.
Department of Chemical Engineering, Yuquan Campus of Zhejiang University, Hangzhou 310027

Received Date: 11 June 2001

Fund Project: Research supported by The Analysis & Test Fund of Zhejiang Province.

L-carnitine selective polymers were prepared by molecular imprinting using methacrylic acid as the functional monomer.The acid function of the monomer is expected to form hydrogen bond and ionic interactions with the amine function of the target molecule L-carnitine.The imprinted polymers were used as stationary phases in high-performance liquid chromatography (HPLC).It was shown that L-carnitine imprinted polymer exhibited a higher affinity to its template molecule, while the non-imprinted polymer had no affinity to the compounds tested.Racemic carnitine hydrochloride was efficiently resolved on the L-carnitine imprinted polymer, and the separation factor is 1.9.
- L-carnitine,
- racemic carnitine hydrochloride,
- molecular imprinting polymer,
- HPLC
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