Citation: Zhe LIU, Gui Jei TIAN, De Xin WANG. An Efficient Synthesis of Cyclopeptides Bridged with Aliphafic-aryl Ether Bond[J]. Chinese Chemical Letters, ;2005, 16(6): 759-762. shu

An Efficient Synthesis of Cyclopeptides Bridged with Aliphafic-aryl Ether Bond

Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union medical college, Beijing 100050

Received Date: 12 July 2004

Fund Project: This work was financially supported by the Grant (No. 30271530) from the National Natural Science Foundation of China. We thank Professor Zeper Abliz and his colleagues for providing mass spectral data, and Mr. Ni Jing-hua for providing AAA data.

Based on the pseudo-dilution effect (PDE) on solid support, three cyclopeptides with an aliphatic-aryl ether bond as the bridge were synthesized via S_N2 reaction between bromoacetylated at N-terminal and the phenol-OH group in C-terminal Tyr residue. All the products were obtained in good overall yields and characterized by related analytic data.
- Intramolecular S_N²reaction,
- cyclopeptide,
- solid-phase organic synthesis,
- pseudo-dilution effect
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