Citation: Ping AI, Jia Chuan LIU, Min ZI, Zhi Hua DENG, Zhi Hong YAN, Li Ming YUAN. Enantioseparation of Aminoglutethimide by High-speed Counter current Chromatography Using Carboxymethly-β-cyclodextrin as Chiral Selector[J]. Chinese Chemical Letters, ;2006, 17(6): 787-790. shu

Enantioseparation of Aminoglutethimide by High-speed Counter current Chromatography Using Carboxymethly-β-cyclodextrin as Chiral Selector

Department of Chemistry, Yunnan Normal University, Kunming 650092

Received Date: 31 October 2005

Fund Project: The work is supported by National Natural Science Foundation of China (No. 30160092), TRAPOYT and Yunnan Province's Natural Science Foundation.

Enantioseparation of aminoglutethimide was performed by high-speed counter-current chromatography with a two-phase system composed of ethyl acetate: methanol: water=10:l:9.The lower phase contained 20 mmol/L of carboxymethly-β-cyclodextrin as chiral selector. The enantiomers were separated in 1.2 h and identified by chiral HPLC. This method was very efficient for the chiral preparative separation.
- High speed countercurrent chromatography,
- enantioseparation,
- aminoglutethimide,
- carboxymethly-β-cyclodextrin
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