Citation: Shao Yi SUN, De Quan YU. Total Synthesis of Antitumor constituent Howiinol A[J]. Chinese Chemical Letters, ;1997, 8(4): 293-294. shu

Total Synthesis of Antitumor constituent Howiinol A

Shao Yi SUN ,
De Quan YU

Institute of Materia Medica, Chinesc Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 24 December 1996

Howiinol A,an active antitumor constituent from the root and stem bark of Goniothamus howii Meer.(Annoaceae) has been synthesized in nine steps from α-D-glucoheptonic γ-lactone with an overall yield of 12.4%;The absolute configuration of natural howiinol A is further confirmed.
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