Citation: Li Jun HUANG, Yan PANG, Ji Mei MIN, Li He ZHANG. Stereoselective Synthesis of N¹-Lyxitol Inosine Derivative[J]. Chinese Chemical Letters, ;2001, 12(7): 575-578. shu

Stereoselective Synthesis of N¹-Lyxitol Inosine Derivative

National Research Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083

Received Date: 10 January 2001

Fund Project: This work was supported by the National Natural Science Foundation of China.

1,4-anhydro-2-triflyl-3,5-O-benzenylidene-L-xylitol (5) was constructed in six steps from protected D-xylose. Substitution of 5 with protected 8-bromoinosine 6 gave the key intermediate 5'-O-TBS-2',3'-di-O-acetyl-N¹-(2"-deoxy-1",4"-anhydro-3",5"-O-benzenylidene-Llyxitol-2"-yl)-8-bromoinosine (14). Selective removal of 5'-O-TBS-group gave the corresponding 5'-O-phosphorodianilidate 4 though phosphorylation, which was characterized by X-ray crystallographic analysis.
- Cyclic ADP-ribose analogues,
- synthesis,
- X-raycrystallographic analysis.
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