Citation: Shi Hua PENG, Tong Hui ZHOU. THE STUDY ON IN VITRO METABOLISM OF BUTYLPHTHALIDE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY[J]. Chinese Chemical Letters, ;1995, 6(1): 55-58.
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The in vitro metabolism o.butylphthalide (HBP) by rat liver microsomes was studied in this paper.Capillary GC/MS and BSTFA/1%TMCS derivatization were used for the separation and structure identification of the six metabolites.3-Hydroxylation and r-hydroxylation have been proved to be the main metabolism pathways of HBP by rat liver microsomes.
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