Citation: Yu Zhen SHI, Zhi Chun CHEN, Na WANG, Qi WU, Xian Fu LIN. Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol:Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic[J]. Chinese Chemical Letters, ;2005, 16(1): 45-48. shu

Lipase-catalyzed Regioselective Synthesis of Vinyl Ester Derivatives of Thiamphenicol:Novel Thiamphenicol Monomers for Preparation of Macromolecular Antibiotic

Yu Zhen SHI ^1,2, ,
Zhi Chun CHEN ¹ ,
Na WANG ¹ ,
Qi WU ¹ ,
Xian Fu LIN ¹

1.
Department of Chemistry, Zhejiang University, Hangzhou 310027;
2.
Department of Chemistry, Hexi College, Zhangye 734000

Received Date: 17 December 2003

Three polymerizable vinyl thiamphenicol esters with different acyl donor carbon chain length (C4, C6, C10) were regioselectivly synthesized by Lipozyme^® (immobilized from mucor miehei) in acetone at 50℃ for 12 h to give 73%, 81%, 63% yield, respectively. The products were valuable monomers for preparation of macromolecular antibiotic.
- Thiamphenicol,
- vinyl ester,
- transesterification,
- regioselectivity,
- monomer.
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