Citation: Chuan Min QI, Zhi Zhong JI. SYNTHESIS AND POTENTIAL ANTINEOPLASTIC ACTIVITY OF α-(1-CYCLOPENTENYL) CYCLOPENTANONE DERIVATIVES-A NEW FAMILY OF ANTICANCER AGENTS[J]. Chinese Chemical Letters, ;1995, 6(10): 847-850. shu

SYNTHESIS AND POTENTIAL ANTINEOPLASTIC ACTIVITY OF α-(1-CYCLOPENTENYL) CYCLOPENTANONE DERIVATIVES-A NEW FAMILY OF ANTICANCER AGENTS

Chuan Min QI ¹ ,
Zhi Zhong JI ²

1.
Department of Applied Chemistry, Peking Agricultural University, Peking 100094;
2.
Shenyang Pharmaceutical University, Shenyang 110015

Received Date: 22 February 1995

Fund Project: The authors thank Liansheng Song, Baofeng Zhang for helpful supports.

In search for anticancer agents,thirteen new α,β-unsaturated and β-aminomethyl cyclopentanones containing α-(1-cyclopentenyl) have been synthesized by condensation and by Mannich reaction respectively.Anticancer test showed that all title compounds have significant activities against P₃₈₅,Hela.HepA and EAC in vitro.Part of these compounds were shown to have activity against EAC tumour in vivo.
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