Citation: Wang Lan, Yang Naidi, Chen Ding, Fang Haixiao, Wu Qiong, Li Lin. Mitochondrial Specific Detection and Regulation[J]. Chemistry, ;2020, 83(6): 488-496. shu

Mitochondrial Specific Detection and Regulation

Institute of Advanced Materials(IAM), Nanjing Tech University, Nanjing, 210009

Corresponding author: Yang Naidi, iamndyang@njtech.edu.cn Li Lin, iamlli@njtech.edu.cn
Received Date: 19 January 2020
Accepted Date: 18 March 2020

Figures(5)

Mitochondria are bilayer-membrane organelles that are found in most cells. They are called as "Energy factories" as they can generate energy through the respiratory chain. Mitochondria are involved in cell differentiation, signaling and apoptosis, and they can also regulate cell growth and cell cycle. Mitochondrial dysfunction is associated with many human diseases such as Parkinson's disease, Alzheimer's disease, cardiovascular disease and cancer. Due to its important role in both cells and organisms, mitochondria have been the focus of research for a long time. This review provides the latest progress of mitochondrial-specific detection and regulation.
- Mitochondria,
- Fluorescent probe,
- Specific detection,
- Mitochondrial regulation
1. [1]
  Lin M T, Beal M F. Nature, 2006, 443(7113): 787~795.
2. [2]
  O'Rourke B. Front. Physiol., 2010, 1: 00007.
3. [3]
  Gao P, Pan W, Li N, et al. Chem. Sci., 2019, 10(24): 6035~6071.
4. [4]
  Li L, Zhang C W, Ge J, et al. Angew. Chem. Int. Ed., 2015, 54(37): 10821~10825.
5. [5]
  Chevalier A, Zhang Y, Khdour O M, et al. J. Am. Chem. Soc., 2016, 138(37): 12009~12012.
6. [6]
  Tan Y, Zhang L, Man K H, et al. ACS Appl. Mater. Interf., 2017, 9(8): 6796~6803.
7. [7]
  Zhang J, Chai X, He X P, et al. Chem. Soc. Rev., 2019, 48(2): 683~722.
8. [8]
  Lu X H, Chen Z J, Dong X C, et al. ACS Sensors, 2018, 3(1): 59~64.
9. [9]
  Bjorn M E, Hasselbalch H C. Mediat. Inflamm., 2015, 648090.
10. [10]
  Shchepinova M M, Cairns A G, Prime T A, et al. Cell Chem. Biol., 2017, 24(10): 1285~1298.e12.
11. [11]
  Wang J, Liu L, Xu W, et al. Anal. Chem., 2019, 91(9): 5786~5793.
12. [12]
  Duan C, Won M, Verwilst P, et al. Anal. Chem., 2019, 91(6): 4172~4178.
13. [13]
  Xie X, Wang J, Yan Y, et al. Analyst, 2018, 143(23): 5736~5743.
14. [14]
  Niu H, Chen K, Xu J, et al. Sens. Actuat. B, 2019, 299: 126938.
15. [15]
  Xu X H, Liu C, Mei Y, et al. J. Mater. Chem. B., 2019, 7(43): 6861~6867.
16. [16]
  Liu Y, Bai L, Li Y H, et al. Sens. Actuat. B, 2019, 279: 38~43.
17. [17]
  Xu J, Zhang Y, Yu H, et al. Anal. Chem., 2016, 88(2): 1455~1461.
18. [18]
  Liu J, Liang J, Wu C, et al. Anal. Chem., 2019, 91(10): 6902~6909.
19. [19]
  Poyton R O, BallK A, Castello P R. Trends Endocrin. Met., 2009, 20(7): 332~340.
20. [20]
  He H, Ye Z, Xiao Y, et al. Anal. Chem., 2018, 90(3): 2164~2169.
21. [21]
  Jia X, Chen Q, Yang Y, et al. J. Am. Chem. Soc., 2016, 138(34): 10778~10781.
22. [22]
  Sun Y Q, Liu J, Zhang H, et al. J. Am. Chem. Soc., 2014, 136(36): 12520~12523.
23. [23]
  Quintana~Cabrera R, Bolanos J P. Biochem. Soc. Trans., 2013, 41: 106~110.
24. [24]
  Wang S, Yin H, Huang Y, et al. Anal. Chem., 2018, 90(13): 8170~8177.
25. [25]
  Yuan P, Mao X, Wu X, et al. Angew. Chem. Int. Ed., 2019, 58(23): 7657~7661.
26. [26]
  Chen J, Jiang X, Zhang C, et al. ACS Sensors, 2017, 2(9): 1257~1261.
27. [27]
  Ji A, Fan Y C, Ren W, et al. ACS Sensors, 2018, 3(5): 992~997.
28. [28]
  Han C, Yang H, Chen M, et al. ACS Appl. Mater. Interf., 2015, 7(50): 27968~27975.
29. [29]
  Zeng Q, Guo Q, Yuan Y, et al. Anal. Chem., 2017, 89(4): 2288~2295.
30. [30]
  Gu Y, Zhao Z, Niu G, et al. ACS Appl. Bio Mater., 2019, 2(7): 3120~3127.
31. [31]
  Yang M, Fan J, Sun W, et al. Anal. Chem., 2019, 91(19): 12531~12537.
32. [32]
  Niu W, Guo L, Li Y, et al. Anal. Chem., 2016, 88(3): 1908~1914.
33. [33]
  Ren T B, Zhang Q L, Su D, et al. Chem. Sci., 2018, 9(24): 5461~5466.
34. [34]
  Zhang X, He N, Huang Y, et al. Sens. Actuat. B., 2019, 282: 69~77.
35. [35]
  Du Z, Zhang R, Song B, et al. Chem. Eur. J., 2019, 25(6): 1498~1506.
36. [36]
  Song G, Liu A, Jiang H, et al. Anal. Chim. Acta., 2019, 1053: 148~154.
37. [37]
  Li S J, Li Y F, Liu H W, et al. Anal. Chem., 2018, 90(15): 9418~9425.
38. [38]
  Wu Z, Liang D, Tang X. Anal. Chem., 2016, 88(18): 9213~9218.
39. [39]
  Han Q, Ru J, Wang X, et al. ACS Appl. Bio. Mater., 2019, 2(5): 1987~1997.
40. [40]
  Park S, Bae D J, Ryu Y M, et al. Chem. Commun., 2016, 52(68): 10400~10402.
41. [41]
  Xiang M H, Huang H, Liu X J, et al. Anal. Chem., 2019, 91(9): 5489~5493.
42. [42]
  Liang B, Shao W, Zhu C, et al. ACS Chem. Biol., 2016, 11(2): 425~434.
43. [43]
  Zhang Q, Li S, Fu C, et al. J. Mater. Chem. B, 2019, 7(3): 443~450.
44. [44]
  Ma D, Huang C, Zheng J, et al. Anal. Chem., 2019, 91(2): 1360~1367.
45. [45]
  Zhang Y, Xia S, Mikesell L, et al. ACS Appl. Bio. Mater., 2019, 2(11): 4986~4997.
46. [46]
  Lan G, Ni K, You E, et al. J. Am. Chem. Soc., 2019, 141(48): 18964~18969.
47. [47]
  Li X Y, Hu Y M, Li X H, et al. Anal. Chem., 2019, 91(17): 11409~11416.
48. [48]
  Sun J, Ling P, Gao F. Anal. Chem., 2017, 89(21): 11703~11710.
49. [49]
  Liu Z, Pei H, Zhang L, et al. ACS Nano, 2018, 12(12): 12357~12368.
50. [50]
  McCormick S P, Moore M J, Lindahl P A. Biochemistry, 2015, 54(22): 3442~3453.
51. [51]
  Li J, Kwon N, Jeong Y, et al. ACS Appl. Mater. Interf., 2018, 10(15): 12150~12154.
52. [52]
  Swamy K M K, Eom S, Liu Y, et al. Sens. Actuat. B, 2019, 281: 350~358.
53. [53]
  Long L L, Huang M Y, Wang N, et al. J. Am. Chem. Soc., 2018, 140(5): 1870~1875.
54. [54]
  Abeywickrama C S, Bertman K A, Plescia C B, et al. ACS Appl. Bio. Mater., 2019, 2(11): 5174~5181.
55. [55]
  Qiao J, Chen C F, Shangguan D H, et al. Anal. Chem., 2018, 90(21): 12553~12558.
56. [56]
  Li L L, Xu H R, Li K, et al. Sens. Actuat. B, 2019, 286: 575~582.
57. [57]
  Wu Z D, Puigserver P, Andersson U, et al. Cell, 1999, 98(1): 115~124.
58. [58]
  Lehman J J, Barger P M, Kovacs A, et al. J. Clin. Invest., 2000, 106(7): 847~856.
59. [59]
  Nisoli E, Clementi E, Paolucci C, et al. Science, 2003, 299(5608): 896~899.
60. [60]
  LeBleu V S, O'Connell J T, Herrera K N G, et al. Nat. Cell Biol., 2014, 16(10): 992~1003.
61. [61]
  Yang W, Nagasawa K, Munch C, et al. Cell, 2016, 167(4): 985~1000.
62. [62]
  Menk A V, Scharping N E, Rivadeneira D B, et al. J. Exp. Med., 2018, 215(4): 1091~1100.
63. [63]
  Huang Q C, Li J B, Xing J L, et al. J. Hepatol., 2014, 61(4): 859~866.
64. [64]
  Li J B, Huang Q C, Long X Y, et al. J. Hepatol., 2015, 63(6): 1378~1389.
65. [65]
  Chen H C, Chan D C. Hum. Mol. Genet., 2009, 18: R169~R176.
66. [66]
  Westermann B. Nat. Rev. Mol. Cell Biol., 2010, 11(12): 872~884.
67. [67]
  Twig G, Elorza A, Molina A J A, et al. EMBO J., 2008, 27(2): 433~446.
68. [68]
  Momcilovic M, Jones A, Bailey S T, et al. Nature, 2019, 575(7782): 380~384.
69. [69]
  Mishra P, Varuzhanyan G, Pham A H, et al. Cell MeTab., 2015, 22(6): 1033~1044.
70. [70]
  Chen M, Chen Z, Wang Y, et al. Autophagy, 2016, 12(4): 689~702.
71. [71]
  Ma J, Zhai Y J, Chen M, et al. PloS One, 2019, 14(1): e0211459.
72. [72]
  Chen Q, Zhang J, Zhao K, et al. Protein Cell, 2014, 5(8): 643~647.
73. [73]
  Zhu P, Liu Y, Zhang F, et al. Cancer Res., 2018, 78(11): 2813~2824.
74. [74]
  Chan N C, Salazar A M, Pham A H, et al. Hum. Mol. Genet., 2011, 20(9): 1726~1737.
75. [75]
  Kim I, Rodriguez-Enriquez S, Lemasters J J. Arch. Biochem. Biophys., 2007, 462(2): 245~253.
76. [76]
  Ashrafi G, Schwarz T L. Cell. Death. Differ., 2013, 20(1): 31~42.
77. [77]
  Zhou Y, Long Q, Wu H, et al. Autophagy, 2020, 16(3): 562~574.
78. [78]
  Dagda R K, Cherra S J, Kulich S M, et al. J. Biol. Chem., 2009, 284(20): 13843~13855.
79. [79]
  Tanaka A, Cleland M M, Xu S, et al. J. Cell Biol., 2010, 191(7): 1367~1380.
80. [80]
  Heo J M, Ordureau A, Paulo J A, et al. Mol. Cell, 2015, 60(1): 7~20.
81. [81]
  Wang L, Cho Y L, Tang Y, et al. Cell Res., 2018, 28(8): 787~802.
82. [82]
  Yan C, Gong L, Chen L, et al. Autophagy, 2020, 16(3): 419~434.
1. [1]
  Jinghan ZHANG , Guanying CHEN . Progress in the application of rare-earth-doped upconversion nanoprobes in biological detection. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2335-2355. doi: 10.11862/CJIC.20240249
2. [2]
  Yingpeng ZHANG , Xingxing LI , Yunshang YANG , Zhidong TENG . A pyrazole-based turn-off fluorescent probe for visual detection of hydrazine. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1301-1308. doi: 10.11862/CJIC.20250064
3. [3]
  Pengli GUAN , Renhu BAI , Xiuling SUN , Bin LIU . Trianiline-derived aggregation-induced emission luminogen probe for lipase detection and cell imaging. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1817-1826. doi: 10.11862/CJIC.20250058
4. [4]
  Yuting DU , Jing YUAN , Peiyao DENG . Synthesis and application of a fluorescent probe for the detection of reduced glutathione. Chinese Journal of Inorganic Chemistry, 2025, 41(7): 1331-1337. doi: 10.11862/CJIC.20240461
5. [5]
  Qiang HU , Zhiqi CHEN , Zhong CHEN , Xu WANG , Weina WU . Pyridinium-chalcone-based ClO^- fluorescent probe: Preparation and biological imaging applications. Chinese Journal of Inorganic Chemistry, 2025, 41(9): 1789-1795. doi: 10.11862/CJIC.20250086
6. [6]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
7. [7]
  Jun LUO , Baoshu LIU , Yunchang ZHANG , Bingkai WANG , Beibei GUO , Lan SHE , Tianheng CHEN . Europium(Ⅲ) metal-organic framework as a fluorescent probe for selectively and sensitively sensing Pb²⁺ in aqueous solution. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2438-2444. doi: 10.11862/CJIC.20240240
8. [8]
  Yubin Su , Chenyu Yao , Shuyan Chen , Lisha Xu , Min Peng , Yawen Wang , Yu Peng , Jianfeng Zheng . 一种聚集诱导发光荧光探针的合成及其在指纹显影中的应用——本科生综合性化学实验探索. University Chemistry, 2026, 41(5): 70-78. doi: 10.12461/PKU.DXHX202511031
9. [9]
  Yanxi LIU , Mengjia XU , Haonan CHEN , Quan LIU , Yuming ZHANG . A fluorescent-colorimetric probe for peroxynitrite-anion-imaging in living cells. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1112-1122. doi: 10.11862/CJIC.20240423
10. [10]
  Shunping WANG , Chuandong GE , Shuguang QU , Tianduo LI , Shaomin WANG , Qingyuan YANG . Synthesis of a fluorescent probe based on urea-based coordination and Si—O bond cleavage for F^- and Cr(Ⅵ) detection. Chinese Journal of Inorganic Chemistry, 2026, 42(2): 297-308. doi: 10.11862/CJIC.20250214
11. [11]
  Xinrong Wu , Yingying Ren , Jianxue Wang , Lijin Yang , Jia Jia , Nan Li , Na Zhao . 聚光捕胺——高灵敏胺响应型聚集诱导发光探针的合成及传感应用. University Chemistry, 2026, 41(5): 180-189. doi: 10.12461/PKU.DXHX202509129
12. [12]
  Yu SU , Xinlian FAN , Yao YIN , Lin WANG . From synthesis to application: Development and prospects of InP quantum dots. Chinese Journal of Inorganic Chemistry, 2024, 40(11): 2105-2123. doi: 10.11862/CJIC.20240126
13. [13]
  Xiaohong Li , Huanjiang Wang , Fang Tan , Xiaohua Cai , Yingchun Luo , Yanli Leng , Guoyong Zhou , Zhu Wen . Research on the Project-Driven Teaching Model in the Context of New Engineering: A Case Study of the Development of a “Portable Metal ions and Pesticide Residues Intelligent Detection System”. University Chemistry, 2026, 41(1): 204-212. doi: 10.12461/PKU.DXHX202510037
14. [14]
  Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002
15. [15]
  Qinqi Zhang , Zhuoran Bi , Yi Zhong , Ziting Xu , Lanlan Chen . 双重信号放大功能核酸荧光探针用于水中抗生素的超灵敏检测. University Chemistry, 2026, 41(5): 448-454. doi: 10.12461/PKU.DXHX202511151
16. [16]
  Meirong HAN , Xiaoyang WEI , Sisi FENG , Yuting BAI . A zinc-based metal-organic framework for fluorescence detection of trace Cu²⁺. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1603-1614. doi: 10.11862/CJIC.20240150
17. [17]
  Yuan ZHU , Xiaoda ZHANG , Shasha WANG , Peng WEI , Tao YI . Conditionally restricted fluorescent probe for Fe³⁺ and Cu²⁺ based on the naphthalimide structure. Chinese Journal of Inorganic Chemistry, 2025, 41(1): 183-192. doi: 10.11862/CJIC.20240232
18. [18]
  Shuwen SUN , Gaofeng WANG . Design and synthesis of a Zn(Ⅱ)-based coordination polymer as a fluorescent probe for trace monitoring 2, 4, 6-trinitrophenol. Chinese Journal of Inorganic Chemistry, 2025, 41(4): 753-760. doi: 10.11862/CJIC.20240399
19. [19]
  Zhifeng CAI , Ying WU , Yanan LI , Guiyu MENG , Tianyu MIAO , Yihao ZHANG . Effective detection of malachite green by folic acid stabilized silver nanoclusters. Chinese Journal of Inorganic Chemistry, 2025, 41(5): 983-993. doi: 10.11862/CJIC.20240394
20. [20]
  Wei GAO , Meiqi SONG , Xuan REN , Jianliang BAI , Jing SU , Jianlong MA , Zhijun WANG . A self-calibrating fluorescent probe for the selective detection and bioimaging of HClO. Chinese Journal of Inorganic Chemistry, 2025, 41(6): 1173-1182. doi: 10.11862/CJIC.20250112

Get Citation

PDF

XML

Metrics

PDF Downloads(19)
Abstract views(2314)
HTML views(703)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142