Citation: Yong Bin HAN, Jin Ping CHEN, Bai Ning LIU, Guo Qiang YANG, Yi LI. Stereochemistry Control in Direct 1α-Hydroxylation of 5, 6-trans-Vitamin D₃ by Solid Support[J]. Chinese Chemical Letters, ;2006, 17(2): 159-162. shu

Stereochemistry Control in Direct 1α-Hydroxylation of 5, 6-trans-Vitamin D₃ by Solid Support

1.
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100101;
2.
Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080

Received Date: 24 May 2005

Fund Project: This work was supported by the Major State Basic Research Development Program (Grant No. F2000078100), the National Natural Science Foundation of China (No. 20172059) and the Found of Chinese Academy of Sciences.

A solid-phase synthesis of 1α-hydroxylation of 5, 6-trans-vitamin D₃ 8 is described.The solid phase resin acts as a special protecting group, which gives a higher stereoselectivity in oxidation step than classical protecting groups. The stereochemistry control is favored by using high crosslinkage polymer support in a poor solvent. This work may be of benefit to the synthesis of vitamin D system.
- Vitamin D₃,
- solid-phase synthesis,
- stereochemistry control
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