Citation: Chun LI, Da Li YIN, Hui Qin HUANG, Xiang Hong WU, Ji Yu GUO. New Stereoselective Synthesis of 4-Butyl-α-agarofuran[J]. Chinese Chemical Letters, ;2003, 14(9): 881-882. shu

New Stereoselective Synthesis of 4-Butyl-α-agarofuran

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 20 September 2002

A potent anxiolytic 4-butyl-α-agarofuran (AF-5) was synthesized from (+)dihydro-carvone.Acid catalyzed hydration of (+)dihydrocarvone and interconversion with β-O-ketone 8 and the key intermediate α,β-unsaturated ketone 5 made this synthesis more practical.
- AF-5,
- stereoselective synthesis
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