Citation: Hai LIU, Jing CHEN, Yang JIANG, Yu Fen ZHAO. Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry[J]. Chinese Chemical Letters, ;2003, 14(2): 195-196. shu

Study on the Enhancement of Proton Affinity by N-Diisopropyloxy Phosphorylation of Amino Acid in Mass Spectrometry

The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084

Received Date: 24 April 2002

Fund Project: The authors thank the National Natural Science Foundation of China (No.20175026)the Ministry of Science and Technology of Chinathe Education Ministry of China and Tsinghua University for financial support.

With introduction of a diisopropyloxy phosphoryl group into the N terminal of amino acids, it was found that proton affinity (PA) of amino acid was enhanced in mass spectrometry.Density functional theory calculations showed that the energy for protonation of DIPP-amino acid is lower than that of amino acid, which means PA of DIPP-AA is higher than that of corresponding amino acid.These results, coincident with our empirical results, offer a useful interpretation of experimental observations.
- Proton affinity,
- diisopropyloxy phosphoryl group,
- amino acid,
- mass spectrometry
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