Citation: Qing Hua ZHOU, Pin YANG. Cleavage of DNA by a New Mixed-ligand Cu(Ⅱ) Complex[J]. Chinese Chemical Letters, ;2005, 16(1): 81-84. shu

Cleavage of DNA by a New Mixed-ligand Cu(Ⅱ) Complex

Qing Hua ZHOU ,
Pin YANG

Institute of Molecular Science, Chemical Biology and Molecular Engineering Laboratory of Education Ministry, Shanxi University, Taiyuan 030006

Received Date: 31 October 2003

Fund Project: The authors acknowledge the support of the National Natural Science Foundation of China (No:20171031) and the Shanxi Provincial Natural Science Foundation for Youth (No:20011007).

Cleavage of DNA pUC19 by [Cu (saldien) (NH₃)]Cl₂ (here, saldien=bis (salicylicdene)-diethylenetriamine) was investigated at different pHs, times, concentrations, and 37℃. It was found that the copper (Ⅱ) complex could cleave DNA without added coreactants.
- Copper (Ⅱ) complex,
- cleavage of DNA,
- saldien.
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