Citation: Chun Ying WEI, Pin YANG, Hai Yan WANG. Na⁺/Ca²⁺ Exchange-mediated La³⁺ Entry in Human Lymphocytes[J]. Chinese Chemical Letters, ;2001, 12(9): 815-816. shu

Na⁺/Ca²⁺ Exchange-mediated La³⁺ Entry in Human Lymphocytes

Institute of Molecular Science, Shanxi University, Taiyuan 030006

Received Date: 15 January 2001

Fund Project: The authors acknowledge the support of the National Natural Science Foundation of China and Provincial Natural Science Foundation of Shanxi

We determined whether La³⁺ enter human peripheral blood lymphocytes via Na⁺/Ca²⁺exchanger (measured with fura-2) We first compared the sensitivity of fura-2 with La³⁺ and Ca²⁺,the result indicates that the sensitiwty of fura-2 for La³⁺ is much greater than for Ca²⁺ . La³⁺ orms a 1:1 La³⁺-fura-2 complex (apparent dissociation constant=l.7%#215;l0-12mol/L, pH 7.05).Ouabain-pretreated cells, suspended in Na⁺-free medium, showed that La³⁺ can enter human lvmphocvtes via the Na⁺_i/Ca²⁺ (La³⁺)_o exchanger and is found to be about 10^-12 mol/L in cells exp osed to 0.4 mmol/L La³⁺. Otherwise, the higher concentration (0.1 mmol/L) blocks theNa⁺_i/Ca²⁺(La³⁺)_o exchange-mediated influx of Ca²⁺, but the lower concentration (0.01 mmol/L)appears to increase Ca²⁺ entry.
- Na+/Ca²⁺exchanger,
- lymphocytes,
- La³⁺,
- ouabain,
- fluorescence indicator
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