Citation: Lian You ZHENG, Xu BAI. Grignard Addition to Quinoxalinium Salt: Synthesis of 1, 2-Dihydroquinoxaline and 1, 2, 3, 4-Tetrahydroquinoxaline Derivatives[J]. Chinese Chemical Letters, ;2006, 17(2): 165-168. shu

Grignard Addition to Quinoxalinium Salt: Synthesis of 1, 2-Dihydroquinoxaline and 1, 2, 3, 4-Tetrahydroquinoxaline Derivatives

Lian You ZHENG ,
Xu BAI

The Center for Combinatorial Chemistry and Drug Discovery, Jilin University, Changchun 130012

Received Date: 8 June 2005

Fund Project: The authors wish to express thanks to Dr. Jin Chang Wu for helpful discussions during the experiments. This work was supported by the grant from Jilin Provincial Fund for Yong Talented Scientists (20010105) and by Changchun Discovery Sciences, Ltd.

Grignard additions to a quinoxalinium salt were studied. Depending on the ratio of the reagents and reaction temperature, 1, 2, 3, 4-tetrahydroquinoxaline and 1, 2-dihydroquinoxaline derivatives could be resulted selectively.
- Grignard addition,
- quinoxalinium salt,
- dihydroquinoxaline,
- tetrahydroquinoxaline
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