Citation: Xiao-jun Huang, Xiao-dan Huang, Ai-fu Che, Zhi-kang Xu, Ke Yao. Suppression of Cell Adhesion on Polyacrylonitrile-Based Membranes by the Anchoring of Phospholipid Moieties[J]. Chinese Journal of Polymer Science, ;2006, 24(1): 103-106. shu

Suppression of Cell Adhesion on Polyacrylonitrile-Based Membranes by the Anchoring of Phospholipid Moieties

Received Date: 13 June 2005
Revised Date: 25 August 2005

In this work, the membrane surface of poly(acrylonitrile-co-2-hydroxyethyl methacrylate) (PANCHEMA) was chemically modified by anchoring of phospholipid moieties. The process involved the reaction of hydroxyl groups on the membrane surface with 2-chloro-2-oxo-1,3,2-dioxaphospholane (COP) followed by the ring-opening reaction of COP with trimethylamine. Chemical differences between the original and the modified membranes were characterized by FT-IR and XPS. It was found that the amount of macrophage adhered on the modified membrane surface is substantially lower than that on polyacrylonitrile (PAN) and PANCHEMA membranes under the same condition. The morphological change of the adherent cell is also suppressed by the generation of phospholipid moieties on the membrane surface.
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