Citation: Xin CHEN, Lin WANG, Zhi Zhong ZHAO, Xing Quan ZHANG, Xiang Hong CHEN, Hong Shan CHEN. Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines[J]. Chinese Chemical Letters, ;2000, 11(7): 571-572. shu

Synthesis of Novel Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors-1-(3-Phthalimido-2-oxobutyl)-4-Substituted-phenylpiperazines

a Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050;
b Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Received Date: 17 January 2000

Fund Project: We acknowledge our thanks to the National Natural Science Foundation of China for the Financial support, Grant No. 39970868.

We have designed and synthesized a series of new phthalimidopiperazines, biological activity test show that the target compounds(Ic, Ie, Ii) can inhibit HIV-1 RT with IC₅₀ 20.0, 43.8, and 63.7 μM, respectively.
- Piperazine,
- phthalimide,
- HIV1-RT inhibitor
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