Citation: Min YANG, Ning CHEN, Xin Fu PAN, Bing Chang QIN. The Synthesis of Podophyllotoxin Derivatives with Macrocyclic Dilactone[J]. Chinese Chemical Letters, ;1999, 10(4): 275-276. shu

The Synthesis of Podophyllotoxin Derivatives with Macrocyclic Dilactone

1.
Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
2.
Department of chemistry, Anyang Teachers College, Anyang 455002

Received Date: 30 November 1998

Fund Project: We thank the National Natural Science Foundation of China (No:29572049) for financial support.

Starting from podophyllotoxin, five new derivatives with macrocyclic dilactone 5~9 have been synthesized,and their structures were confirmed by IR, MS, ¹H NMR as well as HRMS. The key step is cyclization by high dilution method.
- Podophyllotoxin,
- derivatives,
- macrocyclic dilactone,
- synthesis
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