Citation: Jing Hua ZHAO, Tai Gang LIANG, Qing Shan LI, Armando J. L. Pombeiro. Diorgano,Dichloro-tin (Ⅳ) Complexes of 4-X-Benzohydroxamic Acid (X=Cl,OCH₃):Synthesis,Characterization,Antitumor Activity in Vitro and the Crystal Structure of trans-[Me₂Sn(L₂)₂][J]. Chinese Chemical Letters, ;2003, 14(8): 840-843. shu

Diorgano,Dichloro-tin (Ⅳ) Complexes of 4-X-Benzohydroxamic Acid (X=Cl,OCH₃):Synthesis,Characterization,Antitumor Activity in Vitro and the Crystal Structure of trans-[Me₂Sn(L₂)₂]

1.
School of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001;
2.
Complexo I, Instituto Superior Ténico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal

Received Date: 2 September 2002

Fund Project: The financial supports from the National Natural Science Foundation of China (No.39900185), from the State Commission of Science and Technology of China (NO. 96-901-06-38) and from TRAPOYT are gratefully acknowledged.

A series of diorganotin (Ⅳ) derivatives of R₂SnL₂ (R=Me, Et, n-Bu, ph or Cl; L=L₁ or L₂) and their corresponding mixed-ligand complexes R₂Sn(L₁)(L₂) have been prepared and the structure of trans-Me₂Sn(L₂)₂ was characterized by FT-IR, ¹H, ¹³C and ¹¹⁹Sn NMR spectroscopies, MS, elemental analysis, melting points and X-ray diffraction. The structure-activity relationships were discussed.
- Diorganotin,
- X-ray diffraction,
- antitumor activity,
- synthesis
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