Citation: Ping SHEN, San Long WANG, Xi Kui LIU, Chong Ren YANG, Bing CAI, Xin Sheng YAO. A New Steroidal Saponin from Dioscorea deltoidea Wall var.orbiculata[J]. Chinese Chemical Letters, ;2002, 13(9): 851-854. shu

A New Steroidal Saponin from Dioscorea deltoidea Wall var.orbiculata

1.
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016;
2.
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204;
3.
Beijing Institute of Biomedicine, Beijing 100091

Received Date: 21 December 2001

Fund Project: This work was supported by Founds from the Open Lab of Phytochemistry, Kunming Institute of Botany, Chinese Academy of Sciences, and from Ministry of Science and Technology (G1998051113),China. We are grateful to the faculty of the instrument group of Kunming Institute of Botany, Chinese Academy of Sciences, for the measurement of all the spectra, and Prof. Heng Li for her identification of the plant material.

Bioactivity-guided fractionation led to the isolation of a new steroidal saponin,orbiculatoside B, together with a pair of furostanol saponins, protobioside and methyl protobioside,from the fresh rhizomes of Dioscorea deltoidea Wall var. orbiculata. The new compound was identified to be isonarthogenin 3-O-α-L-rhamnopyranosyl (1→2)-[α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside by various NMR techniques in combination with chemical methods. The three saponins showed strong activity against Pyricularia oryzae, and were cytotoxic to cancer cell line K562, HCT-15, A549, and A2780a in vitro.
- Dioscorea deltoidea Wall var.Orbiculata,
- orbiculatoside B,
- Pyricularia oryzae,
- cytotoxic
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