Citation: Chen MA, Tong Hut ZHOU. Studies on Different Hydrolysis Procedures for Drugs of Abuse in Hair[J]. Chinese Chemical Letters, ;1999, 10(3): 239-242. shu

Studies on Different Hydrolysis Procedures for Drugs of Abuse in Hair

Chen MA ,
Tong Hut ZHOU

Institute of Materia Medical Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050

Received Date: 22 September 1998

Different hydrolysis and extraction procedures have been studied for the determination of drugs of abuse in hair samples.The results showed that acid and enzymatic hydrolysis gave high extraction recoveries for 6-monoacetylmorphine.morphine.codeine and heroin.Enzymatic hydrolysis was more expensive.After alkaline hydrolysis.6-monoacetylmorphine.a unique proof of heroin abuse.could not be detected and after methanolic extraction.the extract was dirty and the obtained chromatogram showed an interfering background.It is concluded that acid hydrolysis is the extraction method of choice.
- Drugs of abuse,
- hydrolysis,
- hair
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