Citation: Jun Ying LIU, Yi Yang DONG, Tian Song WANG, Hu Wei LIU, Al Jin HUANG, yi Liang SUNI, Zeng Pei SUN. Separation of chiral drugs with sulfobutylether-β-cyclodextrin by capillary zone electrophoresis[J]. Chinese Chemical Letters, ;1999, 10(1): 39-42. shu

Separation of chiral drugs with sulfobutylether-β-cyclodextrin by capillary zone electrophoresis

a Department of Chemistry, Peking University, Beijing 100871;
b National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050

Received Date: 25 June 1998

Sulfobutylether-β-cyclodextrin (SBE-β-CD) was used as a chiral selector for separating ten chiral drugs with resolution ≥ 1.2 by capillary zone electrophoresis (CZE), The background electrolyte solution comprised of 120 mmol/L Britton-Robinson buffer (BRB) containing 1~10 mmol/L SBE-β-CD with the pH value adjusted from 5.0~6.8. Five of the drugs were better resolved than those previously reported with neutral CDs.
- Chiral separation,
- sulfobutylether-β-cyclodextrin,
- capillary zone electrophoresis,
- anlsodamlne,
- bencynonate,
- econazole,
- esmolol,
- glycopynonate,
- lobeline,
- methoxamine,
- phenylephrine,
- plnacidll,
- terazosin
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