Citation: Wen Hao WANG, Xiao Min ZOU, Xin ZHANG, Yi Qiu FU, Ping XU. Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction[J]. Chinese Chemical Letters, ;2005, 16(5): 585-588. shu

Solid-phase Synthesis of PNA Monomer by Ugi Four-component Condensation Reaction

Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University, Beijing 100083

Received Date: 26 April 2004

Fund Project: This work was supported by the National Basic Research Program (973 Program) from the Ministry of Science and Technology of China (G1998051114) and the National Natural Science Foundation of China (20272004).

Peptide nucleic acids (PNA) oligomers were synthesized in most cases by peptide synthesis from N-protected monomers. In this work a new method of obtaining PNA monomer by Ugi four-component condensation reaction was tested by solid-phase synthesis. The Fmoc protected PNA monomer was build up with thymin-1-yl acetic acid, 3-methylbutyl aldehyde, Fmoc protected aminoethyl isocyanide and Gly-Wang resin.
- Peptide nucleic acids (PNA),
- Ugi four-component condensation reaction (U-4CR),
- Solid-phase synthesis,
- Isocyanide
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