Citation: Yun WU, Jie Cheng XU. Synthesis of Peptoid Nucleic Acid with Thymine as Nucleic Base[J]. Chinese Chemical Letters, ;2000, 11(9): 771-774. shu

Synthesis of Peptoid Nucleic Acid with Thymine as Nucleic Base

Yun WU ,
Jie Cheng XU

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received Date: 13 March 2000

Fund Project: Authors thank the National Natural Science Foundation of China for financial support (29672047).

The synthesis of peptoid nucleic acid bearing thymine as nucleobase has been achieved.This modified oligonucleotide showed good hybridization with DNA.
- Peptoid,
- peptide nucleic acid,
- solid phase synthesis,
- thymine
1. [1]
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2. [2]
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3. [3]
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6. [6]
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7. [7]
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