Citation: Pin YANG, Ai Xin SONG, Xiao Yi FAN. Mechanism of cleaving DNA through hydrolysis of a novel complex of Mg containing dien ligand[J]. Chinese Chemical Letters, ;2000, 11(1): 35-36. shu

Mechanism of cleaving DNA through hydrolysis of a novel complex of Mg containing dien ligand

Institute of Molecular Science, Shanxi University, Taiyuan 030006

Received Date: 20 July 1999

Fund Project: The authors acknowledge the support of the National Natural Science Foundation of China and Provincial Natural Science Foundation of Shanxi.

A series of metal complexes were designed and synthesized and a novel binuclear magnesium complex has been selected, namely[Mg₂(dien)Cl(OH₂)₂]Cl₂·H₂O (dien=diethylene-triamine), which can cleave the plasmid pBR322 DNA effectively in close to physiological condition without adding any external materials. Through biological and chemical methods, especially the comparative experiments, we find the interaction between the complex and DNA belongs to hydrolytic mechanism.
- pBR322 DNA,
- metal complexes,
- dien ligand,
- BDNPP
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2. [2]
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14. [14]
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16. [16]
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17. [17]
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18. [18]
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19. [19]
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20. [20]
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