Citation: Mei HAN, Xu Ling SHI, Zhen Jun YANG, Meng Shen CAI, lie Ming CHENG. CHEMISTRY OF 1, 2, 4-TRIAZINES XIX[J]. Chinese Chemical Letters, ;1993, 4(9): 771-774. shu

CHEMISTRY OF 1, 2, 4-TRIAZINES XIX

School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083

Received Date: 29 April 1993

Fund Project: Director of the project supported by National Natural Science foundation of China.

3-Methylthio-5-hydroxy-1, 2, 4-triazine (1c) reacted with substituted benzenesulfonyl chloride to give 3-methylthio-5-oxy-1, 2, 4-triazin-6-yl pyridinium betaine (4) in anhydrous pyridine.But when NaOH/H₂O/CH₃COCH₃ or NaOH/CH₃OH were used as reactant and solvent, 3-methylthio-4-substituted benzenesulfonyl-5-oxo-6-hydroxy-1, 4, 5, 6-tetrahydro-1, 2, 4-triazine (6) or 1-tosyl-3-methylthio-5-oxo-6-methyloxy-1, 4, 5, 6-tetrahydro-1, 2, 4-triazine (7) was obtained respectively.The above reactions show anomalous properties of nucleophilic attack on 6-carbon in 1, 2, 4-triazine ring.
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