Citation: Pang Xiaoyan, Ge Xin, Ji Jianye, Liang Weijie, Li Zhoujie, Chen Xunjun, Ge Jianfang. Progress in Silylation Protection and Deprotection of Hydroxyl Groups within Alcohol and Phenol[J]. Chemistry, ;2019, 82(1): 37-43. shu

Progress in Silylation Protection and Deprotection of Hydroxyl Groups within Alcohol and Phenol

1.
College of Chemical, ZhongKai University of Agriculture and Engineering, Guangzhou 510225
2.
School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072

Corresponding author: Ge Jianfang, ge650704@163.com
Received Date: 31 July 2018
Accepted Date: 17 September 2018

Figures(2)

Silylation protection of hydroxyl groups within alcohol and phenol is an important class of organic synthesis, which means to stabilize the hydroxyl groups and eliminate or mitigate the side reactions caused by them. The smaller steric hindrance of the group attached to the silicon atom in the protecting group, the greater reactivity of the protecting group, and the worse stability of the corresponding silyl ether be formed. It can be removed under weak acid or weak base conditions. The larger steric hindrance of the group attached to the silicon atom, the smaller reactivity of the protecting group, and the more difficult of silylation reaction, which requires the use of a catalyst. This article describes the types of organosilane protecting groups, such as trimethylsilane, triethylsilane, tert-butyldimethylsilane, triisopropylsilane, phenyl-substituted silane and bridging silane. The activity and stability of the protecting group under different environments are also discussed.
- Silylation,
- Hydroxyl,
- Chemical reaction
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沈阳化工大学材料科学与工程学院沈阳 110142