Citation: Cheng Bin CUI, Qing Chun ZHAO, Bing CAI, Xin Sheng YAO, Hiroyouki OSADA. A New Polyphenolic Compound from Rubus aleaefolius and Its Inhibitory Activity on Mammalian Cell Cycle at G₀/G₁ Phase[J]. Chinese Chemical Letters, ;2002, 13(4): 327-330. shu

A New Polyphenolic Compound from Rubus aleaefolius and Its Inhibitory Activity on Mammalian Cell Cycle at G₀/G₁ Phase

1.
Beijing Institute of Biomedicine, Beijing 100091;
2.
Shenyang Pharmaceutical University, Shenyang 110016;
3.
Marine Drug and Food Institute, Qingdao Ocean University, Qingdao 266003;
4.
The Institute of Physical and Chemical Research (R1KEN), Saitama 351-0198, Japan

Received Date: 11 July 2001

Fund Project: We thank Prof. Q. Sun and Mrs. G. Qu, both of Shenyang Pharmaceutical University, for their contributions on the collection and identification of the plant materials. This work was supported by the Found from NNSFC (C. Cui, No. 39825126) and the Found from Ministry of Science and Technology for 973-project (C. Cui, No. G1998051113),China.

Rubuphenol (1),a new polyphenolic compound,was isolated together with the known ellagic acid (2) as new cell cycle inhibitors from Rubus aleaefolius Poir.through a bioassay-guided separation procedure and the structure of 1 was elucidated by spectroscopic method.Compounds 1 and 2 inhibited the cell cycle of tsFT210 cells at the G₀/G₁ phase respectively with the MIC values of 14.6μM and 10.3μM.
- Rubuphenol,
- ellagic acid,
- polyphenol,
- Rubus aleaefolius,
- cell cycle inhibitor
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