Citation: Shou Hai GAO, Liu Hong YUN. SYNTHESIS AND ANTICHOLINERGIC ACTIVITIES OF 6,11-DIHYDRODIBENZ［b,e］OXEPIN AND 6,11-DIHYDRODIBENZO［b,e］THIEPIN HYDROXYCARBOXYLATES[J]. Chinese Chemical Letters, ;1996, 7(2): 115-118. shu

SYNTHESIS AND ANTICHOLINERGIC ACTIVITIES OF 6,11-DIHYDRODIBENZ［b,e］OXEPIN AND 6,11-DIHYDRODIBENZO［b,e］THIEPIN HYDROXYCARBOXYLATES

Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, 100850

Received Date: 5 June 1995

New tricyclic hydroxycarboxylates-dibenz[b,e]oxepin and dibenzo[b,e]thiepin hydroxycarboxylates (7) were synthesized by modifying the structures of xanthene compounds.The pharmacological results showed the antagonistic activities of these tricyclic compounds were all decreased at different levels after this modification,but they exhibited more selective action on the central nicotinic receptor.Especially,the compounds containing sulfur atom almost have no action on the muscarinic receptors,they were still quite potent to the central nicotinic receptor.
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