Citation: Guo Qiang HU, Wen Long HUANG, Hui Bin ZHANG, Hai WANG. Synthesis and Their Endothelium Vascular Relaxation of Arecoline Derivatives Containing Oxadiazoline[J]. Chinese Chemical Letters, ;2002, 13(9): 814-817. shu

Synthesis and Their Endothelium Vascular Relaxation of Arecoline Derivatives Containing Oxadiazoline

1.
China pharmaceutical University, Nanjing 210009;
2.
Academy of Military Medical Sciences, Beijing 100850

Received Date: 24 September 2001

Fund Project: Fianncial support of this work by the State Key Basic Research and Development Project (No.G 1998051112).

Ten novel 1,1-dimethyl-3-(2-or 5-aryl-4-acetyl-2,3-dihydro-1,3,4-oxadiazoline-5-or-2-yl)-1,2,5,6-tetrahydropyridinium iodides were synthesized from starting material nicotinalde-hyde or nicotinic acid by two different synthetic methods respectively. The preliminary bioactive tests indicate som compounds exhibit potent relaxing effect on endothelial cells, comparable to Ach or arecoline.
- Arecoline derivatives,
- oxadiazoline,
- muscarinic agonist,
- EPA,
- relaxing effect
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