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Citation:
Xiu Feng LIU, Hui Ming ZHU, Tuan Wei ZHANG, Bao Quan ZHANG. Effect of Supercritical Fluids on the Biological Activity of Absidia coerulea for the Hydroxylation of Reichsterin's Substance Acetate[J]. Chinese Chemical Letters,
;2005, 16(1): 107-110.
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The viability and biological activity of Absidia coerulea in compressed or supercritical CO2 and C2H4 were studied. The specific activity ofAbsidia coerulea in 7.5MPa CO2 and C2H4 at 306K can reach to 23% and 75% respectively, leading to the feasibility of using supercritical C2H4as an alternative to the organic solvent in the hydroxylation of Reichsterin's substance acetate.
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Keywords:
- Absidia coerulea,
- hydroxylation,
- hydrocortisone,
- supercritical fluids.
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