Citation: LI Fei-Ran, ZHANG Xin, WANG Dong-Dong, XUE Zhi-Na, MA Ying-Ke. Syntheses, Crystal Structures and Antibacterial Activities of Schiff Base Ligand and Its Nickel(Ⅱ) Complex[J]. Chinese Journal of Structural Chemistry, ;2014, 33(9): 1367-1374. shu

Syntheses, Crystal Structures and Antibacterial Activities of Schiff Base Ligand and Its Nickel(Ⅱ) Complex

1.
Tianjin Key Laboratory of Structure and Performance for Functional Molecule, College of Chemistry, Tianjin Normal University, Tianjin 300387, China

Corresponding author: ZHANG Xin,
Received Date: 17 February 2014
Available Online: 3 July 2014

A complex[NiL₂] was synthesized, in which L, or to be exact, a Schiff base ligand (HL), was derived from the condensation of 1-phenyl-3-methyl-4-phenylacetyl-5-pyrazolone (PMPAP) with L-phenylalanine methyl ester. They were characterized by IR and single-crystal X-ray diffraction. Green block crystals of both ligand and its complex were grown at room temperature. The ligand, which consists of two individual fragments, crystalizes in the P1 space group (a=5.6268(5), b=10.6892(11) and c=19.4869(18) Å). The complex crystalizes in the P2₁ space group (a=21.4076(18), b=9.4792(8) and c=25.287(2) Å), which consists of a nickel six-coordinated compound. Every fragment is a distorted octahedron with four oxygen and two nitrogen atoms. The Schiff base ligand (HL) and its complex have been tested in vitro to evaluate their antibacterial activity against bacteria Escherichia Coli and Bacillus subtilis. It is found that the complex has higher activity than the corresponding free Schiff base ligand (HL) against the same bacterial.
- Schiff base,
- complex,
- crystal structure,
- antibacterial activity
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