Citation: Wei WANG, Xiao Yun FU, Yao Zu CHEN. Carboxymethyl-β-Cyclodextrin for Chiral Separation of Basic Drugsby Capillary Elcctrophoresis[J]. Chinese Chemical Letters, ;1999, 10(10): 831-832. shu

Carboxymethyl-β-Cyclodextrin for Chiral Separation of Basic Drugsby Capillary Elcctrophoresis

1.
Analytical and Testing Center Zhejiang University Hangzhou 310027;
2.
State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

Received Date: 12 April 1999

Four basic drugs were separated by capillary electrophoresis (CE) using carboxymethyl-β-cyclodextrin (CM-β-CD) as chiral selector The effects of CM-β-CD concentration, applied voltage, operation temperature were investigated. Under the selected conditions; norephedrine, ofloxacin; terbutaline and chlorpheniramine were enantiomerally baseline-separated using H₃P0₄-triethanolamine buffer at pH 3 containing 10, 5.5, 2, 2mmo1/L CM-β-CD respectively.
- Capillary electrophoresis,
- chiral separation,
- carboxymethyl-β-cyclodextrin,
- basicdrugs
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