Citation: Yu Chanchan, Yao Li. Advances in Biological Single-Molecule Force Spectroscopy[J]. Chemistry, ;2016, 79(4): 292-298. shu

Advances in Biological Single-Molecule Force Spectroscopy

Yu Chanchan ,
Yao Li

1.
Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190

Received Date: 22 October 2015
Available Online: 4 December 2015

In recent years, single-molecule force spectroscopy has been developed rapidly and applied in various fields. The investigation of biological structure, mechanical property, and molecular dynamics by single-molecule force spectroscopy can reveal the mechanism of intermolecular interaction at the single-molecule level. It will greatly help us understand the molecular recognition, biochemical process and the relationship between molecular structure and functions. This paper introduces three kinds of the most common single-molecule force spectroscopy: atomic force microscopy (AFM), optical tweezers (OT), and magnetic tweezers (MT) at first. Then the basic principle, development, and applications of other three kinds of massively parallel force spectroscopy: acoustic force spectroscopy (AFS), centrifugal force microscope (CFM), and force-induced remnant magnetization spectroscopy (FIRMS) are introduced briefly.
- Single-molecule force spectroscopy,
- Biological molecules,
- Intermolecular interaction
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