Citation: Hamzeh Kiyani, Maryam Ghiasi. Potassium phthalimide: An efficient and green organocatalyst for the synthesis of 4-aryl-7-(arylmethylene)-3, 4, 6, 7-tetrahydro-1Hcyclopenta[d]pyrimidin-2(5H)-ones/thiones under solvent-free conditions[J]. Chinese Chemical Letters, ;2014, 25(2): 313-316. shu

Potassium phthalimide: An efficient and green organocatalyst for the synthesis of 4-aryl-7-(arylmethylene)-3, 4, 6, 7-tetrahydro-1Hcyclopenta[d]pyrimidin-2(5H)-ones/thiones under solvent-free conditions

Hamzeh Kiyani ^, ,
Maryam Ghiasi

1.
School of Chemistry, Damghan University, Damghan 36715-365, Iran

Corresponding author: Hamzeh Kiyani,
Received Date: 11 July 2013
Available Online: 6 November 2013

An efficient synthesis of Biginelli-type compounds using potassium phthalimide as a green, mild, and commercially available organocatalyst in a one-pot, multi-component cyclocondensation reaction of cyclopentanone, aldehydes, and urea/thiourea is reported. The present methodology is a green approach to access 4-aryl-7-(arylmethylene)-3,4,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-2(5H)-ones/thiones. It offers several merits such as simple operational procedures, no use of hazardous organic solvents, and cheap and environmentally friendly solid basic catalyst.
- Organocatalyst,
- Potassium phthalimide,
- Biginelli reaction,
- Pyrimidinone,
- Solvent-free
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