Citation: Quan Zhang, Zhou Ye, Shu-Ting Wang, Jian Yin. Facile one-pot synthesis of PEGylated monodisperse mesoporous silica nanoparticles with controllable particle sizes[J]. Chinese Chemical Letters, ;2014, 25(2): 257-260. shu

Facile one-pot synthesis of PEGylated monodisperse mesoporous silica nanoparticles with controllable particle sizes

1.
The Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, China

Corresponding author: Quan Zhang, Jian Yin,
Received Date: 4 June 2013
Available Online: 23 October 2013
Fund Project:

In this work, we describe the one-pot synthesis of PEGylated mesoporous silica nanoparticles (MSNs) with uniform shape, tunable sizes, and narrow size distributions. The size of these nanoparticles can be controlled from 49 nmto 98 nmby simply varying the concentration of triethanolamine during the basecatalyzed sol-gel reaction. Particles were characterized by transmission electron microscopy, dynamic light scattering, Fourier transform infrared spectrometry, thermogravimetric analysis, and nitrogen adsorption-desorption measurements. These PEGylated MSNs exhibited excellent long-term stability in biological media, which ensures their potential applications in drug delivery.
- Mesoporous silica nanoparticles,
- Monodisperse,
- PEGylated modification,
- Stability
1. [1]
  [1] B.G. Trewyn, S. Giri, I.I. Slowing, V.S. Lin, Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems, Chem. Commun. (31) (2007) 3236-3245.
2. [2]
  [2] Q.J. He, J.L. Shi, Mesoporous silica nanoparticle based nano drug delivery systems: synthesis, controlled drug release and delivery, pharmacokinetics and biocompatibility, J. Mater. Chem. 21 (2011) 5845-5855.
3. [3]
  [3] F.Q. Tang, L.L. Li, D. Chen, Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery, Adv. Mater. 24 (2012) 1504-1534.
4. [4]
  [4] Y.Y. Pu, Y. Li, W. Zhuang, et al., Preparation and characterizations of helical mesoporous silica nanorods using CTAB and alcohols, Chin. Chem. Lett. 23 (2012) 1201-1204.
5. [5]
  [5] Q. Zhang, F. Liu, K.T. Nguyen, et al., Multifunctional mesoporous silica nanoparticles for cancer-targeted and controlled drug delivery, Adv. Funct. Mater. 22 (2012) 5144-5156.
6. [6]
  [6] S.H. Wu, Y.S. Lin, Y. Hung, et al., Multifunctional mesoporous silica nanoparticles for intracellular labeling and animal magnetic resonance imaging studies, Chem- BioChem 9 (2008) 53-57.
7. [7]
  [7] Q.J. He, Z.W. Zhang, F. Gao, Y. Li, J.L. Shi, In vivo biodistribution and urinary excretion of mesoporous silica nanoparticles: effects of particle size and PEGylation, Small 7 (2011) 271-280.
8. [8]
  [8] K.M.L. Taylor, J.S. Kim, W.J. Rieter, et al., Mesoporous silica nanospheres as highly efficient MRI contrast agents, J. Am. Chem. Soc. 130 (2008) 2154-2155.
9. [9]
  [9] J. Kim, J.E. Lee, J. Lee, et al., Magnetic fluorescent delivery vehicle using uniform mesoporous silica spheres embedded with monodisperse magnetic and semiconductor nanocrystals, J. Am. Chem. Soc. 128 (2006) 688-689.
10. [10]
  [10] B. Haley, E. Frenkel, Nanoparticles for drug delivery in cancer treatment, Urol. Oncol.: Semin. Orig. Invest. 26 (2008) 57-64.
11. [11]
  [11] F. Danhier, O. Feron, V. Pré at, To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery, J. Controlled Release 148 (2010) 135-146.
12. [12]
  [12] Q.J. He, J.M. Zhang, J.L. Shi, et al., The effect of PEGylation of mesoporous silica nanoparticles on nonspecific binding of serum proteins and cellular responses, Biomaterials 31 (2010) 1085-1092.
13. [13]
  [13] H. Meng, M. Xue, T. Xia, et al., Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model, ACS Nano 5 (2011) 4131-4144.
14. [14]
  [14] V. Cauda, C. Argyo, T. Bein, Impact of different PEGylation patterns on the longterm bio-stability of colloidal mesoporous silica nanoparticles, J. Mater. Chem. 20 (2010) 8693-8699.
15. [15]
  [15] V. Cauda, A. Schlossbauer, T. Bein, Bio-degradation study of colloidal mesoporous silica nanoparticles: effect of surface functionalization with organo-silanes and poly(ethylene glycol), Microporous Mesoporous Mater. 132 (2010) 60-71.
16. [16]
  [16] Y.S. Lin, N. Abadeer, C.L. Haynes, Stability of small mesoporous silica nanoparticles in biological media, Chem. Commun. 47 (2011) 532-534.
17. [17]
  [17] K. Möller, J. Kobler, T. Bein, Colloidal suspensions of nanometer-sized mesoporous silica, Adv. Funct. Mater. 17 (2007) 605-612.
18. [18]
  [18] Q. Zhang, C.H. Wang, L. Qiao, H.S. Yan, K.L. Liu, Superparamagnetic iron oxide nanoparticles coated with a folate-conjugated polymer, J. Mater. Chem. 19 (2009) 8393-8402.
1. [1]
  Jiaxu Wang , Jinxie Zhang , Xiuping Wang , Jingying Wang , Lina Chen , Jiahui Cao , Wei Cao , Siyu Liang , Ping Luan , Ke Zheng , Xiao-Kun Ouyang , Li Gao , Xiaowen Ou , Fan Zhang , Meitong Ou , Lin Mei . CaCO₃-coated hollow mesoporous silica nanoparticles for pH-responsive fungicides release. Chinese Chemical Letters, 2024, 35(12): 109697-. doi: 10.1016/j.cclet.2024.109697
2. [2]
  Chenghao Ge , Peng Wang , Pei Yuan , Tai Wu , Rongjun Zhao , Rong Huang , Lin Xie , Yong Hua . Tuning hot carrier transfer dynamics by perovskite surface modification. Chinese Chemical Letters, 2024, 35(10): 109352-. doi: 10.1016/j.cclet.2023.109352
3. [3]
  Jingyuan Yang , Xinyu Tian , Liuzhong Yuan , Yu Liu , Yue Wang , Chuandong Dou . Enhancing stability of diradical polycyclic hydrocarbons via P=O-attaching. Chinese Chemical Letters, 2024, 35(8): 109745-. doi: 10.1016/j.cclet.2024.109745
4. [4]
  Ting Wang , Xin Yu , Yaqiang Xie . Unlocking stability: Preserving activity of biomimetic catalysts with covalent organic framework cladding. Chinese Chemical Letters, 2024, 35(6): 109320-. doi: 10.1016/j.cclet.2023.109320
5. [5]
  Qiyan Wu , Ruixin Zhou , Zhangyi Yao , Tanyuan Wang , Qing Li . Effective approaches for enhancing the stability of ruthenium-based electrocatalysts towards acidic oxygen evolution reaction. Chinese Chemical Letters, 2024, 35(10): 109416-. doi: 10.1016/j.cclet.2023.109416
6. [6]
  Xingang Kong , Yabei Su , Cuijuan Xing , Weijie Cheng , Jianfeng Huang , Lifeng Zhang , Haibo Ouyang , Qi Feng . Facile synthesis of porous TiO₂/SnO₂ nanocomposite as lithium ion battery anode with enhanced cycling stability via nanoconfinement effect. Chinese Chemical Letters, 2024, 35(11): 109428-. doi: 10.1016/j.cclet.2023.109428
7. [7]
  Xinpin Pan , Yongjian Cui , Zhe Wang , Bowen Li , Hailong Wang , Jian Hao , Feng Li , Jing Li . Robust chemo-mechanical stability of additives-free SiO₂ anode realized by honeycomb nanolattice for high performance Li-ion batteries. Chinese Chemical Letters, 2024, 35(10): 109567-. doi: 10.1016/j.cclet.2024.109567
8. [8]
  Hongmei Yu , Baoxi Zhang , Meiju Liu , Cheng Xing , Guorong He , Li Zhang , Ningbo Gong , Yang Lu , Guanhua Du . Theoretical and experimental cocrystal screening of temozolomide with a series of phenolic acids, promising cocrystal coformers. Chinese Chemical Letters, 2024, 35(5): 109032-. doi: 10.1016/j.cclet.2023.109032
9. [9]
  Wenxiang Ma , Xinyu He , Tianyi Chen , De-Li Ma , Hongzheng Chen , Chang-Zhi Li . Near-infrared non-fused electron acceptors for efficient organic photovoltaics. Chinese Chemical Letters, 2024, 35(4): 109099-. doi: 10.1016/j.cclet.2023.109099
10. [10]
  Liang Ming , Dan Liu , Qiyue Luo , Chaochao Wei , Chen Liu , Ziling Jiang , Zhongkai Wu , Lin Li , Long Zhang , Shijie Cheng , Chuang Yu . Si-doped Li₆PS₅I with enhanced conductivity enables superior performance for all-solid-state lithium batteries. Chinese Chemical Letters, 2024, 35(10): 109387-. doi: 10.1016/j.cclet.2023.109387
11. [11]
  Rui Liu , Yue Yu , Lu Deng , Maoxia Xu , Haorong Ren , Wenjie Luo , Xudong Cai , Zhenyu Li , Jingyu Chen , Hua Yu . The synergistic effect of A-site cation engineering and phase regulation enables efficient and stable Ruddlesden-Popper perovskite solar cells. Chinese Chemical Letters, 2024, 35(12): 109545-. doi: 10.1016/j.cclet.2024.109545
12. [12]
  Yan-Kai Zhang , Yong-Zheng Zhang , Chun-Xiao Jia , Fang Wang , Xiuling Zhang , Yuhang Wu , Zhongmin Liu , Hui Hu , Da-Shuai Zhang , Longlong Geng , Jing Xu , Hongliang Huang . A stable Zn-MOF with anthracene-based linker for Cr(VI) photocatalytic reduction under sunlight irradiation. Chinese Chemical Letters, 2024, 35(12): 109756-. doi: 10.1016/j.cclet.2024.109756
13. [13]
  Jinqiang Gao , Haifeng Yuan , Xinjuan Du , Feng Dong , Yu Zhou , Shengnan Na , Yanpeng Chen , Mingyu Hu , Mei Hong , Shihe Yang . Methanol steam mediated corrosion engineering towards high-entropy NiFe layered double hydroxide for ultra-stable oxygen evolution. Chinese Chemical Letters, 2025, 36(1): 110232-. doi: 10.1016/j.cclet.2024.110232
14. [14]
  Rongjun Zhao , Tai Wu , Yong Hua , Yude Wang . Improving performance of perovskite solar cells enabled by defects passivation and carrier transport dynamics regulation via organic additive. Chinese Chemical Letters, 2025, 36(2): 109587-. doi: 10.1016/j.cclet.2024.109587
15. [15]
  Guilong Li , Wenbo Ma , Jialing Zhou , Caiqin Wu , Chenling Yao , Huan Zeng , Jian Wang . A composite hydrogel with porous and homogeneous structure for efficient osmotic energy conversion. Chinese Chemical Letters, 2025, 36(2): 110449-. doi: 10.1016/j.cclet.2024.110449
16. [16]
  Guizhi Zhu , Junrui Tan , Longfei Tan , Qiong Wu , Xiangling Ren , Changhui Fu , Zhihui Chen , Xianwei Meng . Growth of CeCo-MOF in dendritic mesoporous organosilica as highly efficient antioxidant for enhanced thermal stability of silicone rubber. Chinese Chemical Letters, 2025, 36(1): 109669-. doi: 10.1016/j.cclet.2024.109669
17. [17]
  Jiaxi Xu , Yuan Ma . Influence of Hyperconjugation on the Stability and Stable Conformation of Ethane, Hydrazine, and Hydrogen Peroxide. University Chemistry, 2024, 39(11): 374-377. doi: 10.3866/PKU.DXHX202402049
18. [18]
  Hailian Tang , Siyuan Chen , Qiaoyun Liu , Guoyi Bai , Botao Qiao , Fei Liu . Stabilized Rh/hydroxyapatite Catalyst for Furfuryl Alcohol Hydrogenation: Application of Oxidative Strong Metal-Support Interactions in Reducing Conditions. Acta Physico-Chimica Sinica, 2025, 41(4): 100036-. doi: 10.3866/PKU.WHXB202408004
19. [19]
  Shitao Fu , Jianming Zhang , Cancan Cao , Zhihui Wang , Chaoran Qin , Jian Zhang , Hui Xiong . Study on the Stability of Purple Cabbage Pigment. University Chemistry, 2024, 39(4): 367-372. doi: 10.3866/PKU.DXHX202401059
20. [20]
  Zhaomin Tang , Qian He , Jianren Zhou , Shuang Yan , Li Jiang , Yudong Wang , Chenxing Yao , Huangzhao Wei , Keda Yang , Jiajia Wang . Active-transporting of charge-reversal Cu(Ⅱ)-doped mesoporous silica nanoagents for antitumor chemo/chemodynamic therapy. Chinese Chemical Letters, 2024, 35(7): 109742-. doi: 10.1016/j.cclet.2024.109742

Get Citation

PDF

XML

Metrics

PDF Downloads(0)
Abstract views(704)
HTML views(11)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142