Citation: Ye Li, Kun-Lai Sun, Yi Wang, Peng Fu, Pei-Pei Liu, Chen Wang, Wei-Ming Zhu. A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2[J]. Chinese Chemical Letters, ;2013, 24(12): 1049-1052. shu

A cytotoxic pyrrolidinoindoline diketopiperazine dimer from the algal fungus Eurotium herbariorum HT-2

1.
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China

Corresponding author: Wei-Ming Zhu,
Received Date: 7 April 2013
Available Online: 25 June 2013
Fund Project: This work is financially supported by NSFC (No. 21172204) & NSFS (No. ZR2009CQ014) (No. 21172204) and Scientific Research Foundation for the Returned Overseas Chinese Scholars, Ministry of Education of China (No. [2010]1174). (No. 2010CB833804)

A new cytotoxic pyrrolidinoindoline diketopiperazine dimer, cristatumin E (1), was isolated from the fermentation broth of the algal fungus Eurotium herbariorum HT-2 associated with the marine algae, Enteromorpha prolifera. The structure was determined by spectroscopic analyses and Marfey's amino acid analysis. Cristatumin E (1) showed cytotoxicity against K562 tumor cell line and antibacterial activity against Enterobacter aerogenes and Escherichia coli with IC₅₀ and MIC values of 8.3, 44.0 and 44.0 μmol/L, respectively.
- Cristatumin E,
- Pyrrolidinoindoline diketopiperazine dimer,
- Eurotium herbariorum,
- Algal fungus,
- Cytotoxicity,
- Enteromorpha prolifera,
- Marine algae
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