Citation: Xia-Shi Lv, Yong-Mei Cui, He-Yun Wang, Hai-Xia Lin, Wei-Ya Ni, Tomohiko Ohwada, Katsutoshi Ido, Kohei Sawada. Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid[J]. Chinese Chemical Letters, ;2013, 24(11): 1023-1026. shu

Synthesis and BK channel-opening activity of novel N-acylhydrazone derivatives from dehydroabietic acid

1.
a Department of Chemistry, College of Sciences, Shanghai University, Shanghai 200444, China;
2.
b Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan;
c Tsukuba Research Laboratories, Eisai Co.
c Tsukuba Research Laboratories, Eisai Co. Ltd, Ibaraki 300-2635, Japan

Corresponding author: Hai-Xia Lin,
Received Date: 16 April 2013
Available Online: 5 June 2013

A series of hydrazone and N-acylhydrazone derivatives of dehydroabietic acid were synthesized and evaluated for BK channel-opening activities in an assay system of CHO-K1 cells expressing hBKa channels. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at hydrazone moiety.
- BK channels,
- Openers,
- Dehydroabietic acid,
- N-Acylhydrazone
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