Citation: Kai Wanga, Shuai-Hua Song, Yun-Man Zheng, Zao-Ying Li. Morphological characterization of amidinophenylporphyrins interacting with DNA by photo irradiation[J]. Chinese Chemical Letters, ;2013, 24(11): 1011-1013. shu

Morphological characterization of amidinophenylporphyrins interacting with DNA by photo irradiation

1.
a Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430073, China;
2.
b College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

Corresponding author: Kai Wanga, Zao-Ying Li,
Received Date: 16 May 2013
Available Online: 8 July 2013

5,10,15,20-Tetrakis(4-amidinophenyl)porphyrin (Por 1), its Zn complex (Por 2) and amidinophenyl bispophyrin (Por 3) interacting with calf thymus DNA were investigated by scanning electron microscopy (SEM) and the shape and size of the porphyrin-DNA complexes were observed after photo irradiation. The results showed that the shape and size of DNA had significant differences with blank group by virtue of the interaction between the porphyrins and ct-DNA. This suggests the morphological characterization could be used to study the interaction and judge DNA photocleavage activity indirectly through the photo irradiation of porphyrins.
- Amidinophenylporphyrin,
- DNA,
- Scanning electron microscopy,
- Photo irradiation
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沈阳化工大学材料科学与工程学院沈阳 110142