Citation: Yue-Jie Chen, Rui-Yang Bao, Xiao-Dong Zhang, Ye-Feng Tang. Formal synthesis of (+)-tashiromine and study toward the total synthesis of (+)-stemoamide[J]. Chinese Chemical Letters, ;2013, 24(11): 953-956. shu

Formal synthesis of (+)-tashiromine and study toward the total synthesis of (+)-stemoamide

1.
The Comprehensive AIDS Research Center, Department of Pharmacology & Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China

Corresponding author: Ye-Feng Tang,
Received Date: 26 April 2013
Available Online: 24 June 2013

An efficient formal synthesis of (+)-tashiromine was achieved by employing an intermolecular asymmetric Mannich-type reaction as the key step. Concurrently, a novel approach toward the total synthesis of (+)-stemoamide through dyotropic rearrangement of 3,4-cis-β-lactone was also explored.
- Stemoamide,
- Tashiromine,
- Dyotropic rearrangement,
- β-Lactone,
- Total synthesis
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