Citation: Ting Zhang, Zheng Yan, Yun-Feng Li, Nan Wang. Simplified aminocoumarin analogues as anticancer agents： Amino isosteric replacement in the noviose moiety resulted in substantial enhancement of antiproliferative activity[J]. Chinese Chemical Letters, ;2013, 24(8): 719-722. shu

Simplified aminocoumarin analogues as anticancer agents： Amino isosteric replacement in the noviose moiety resulted in substantial enhancement of antiproliferative activity

1.
State Key Laboratory of Bioactive Substance and Function of Natural Medicine, Beijing Key Laboratory of Active Substance Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China

Corresponding author: Yun-Feng Li, Nan Wang,
Received Date: 5 March 2013
Available Online: 18 April 2013

Simplified aminocoumarin analogues, either noviosylated or simple basic heterocycle attached 3-amidocoumarin compounds, are known to be promising anticancer agents targeting the C-terminal ATPbinding site of Hsp90. In this study, 3'-amino isosteric replacement in the noviose moiety of two known noviose containing Hsp90 C-terminal inhibitors was synthetically realized for the first time. In vitro evaluation of these compounds suggested that the introduction of a basic amino group into the noviose subunit resulted in significant improvement of their cytotoxicities.
- 3-Amino-3-deoxy-L-noviose,
- Aminocoumarin analogues,
- Cytotoxicity,
- Hsp90 inhibitors
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沈阳化工大学材料科学与工程学院沈阳 110142